Researching therapies for gastrointestinal (GI) diseases
When your body already holds the answer
Researching therapies for gastrointestinal (GI) diseases
When your body already holds the answer
When your body already holds the answer
When your body already holds the answer
We are a research based biopharmaceutical company focused on discovering therapies for patients with liver and gastrointestinal (GI) diseases. Our most advanced research focuses on understanding the farnesoid X receptor (FXR), which is central to modulating liver and GI diseases
In January 2020, only nine months after having set up the research lab, rapid progress has been made in discovering and characterizing distinct chemical entities towards a novel therapeutic target for FXR which is central to modulating liver and GI diseases. During this first phase of the research, we have solved a crystallographic structure of the protein targeted by our team. Additionally, Revitocrine established a selective assay and screened its proprietary library of approximately 20.000 distinct novel fragments.
This fragment screen revealed hits from a number of distinctive different chemotypes that specifically bound to the active site of the target protein. Each of these chemotypes has been validated and the binding mode was determined by crystallography to develop the most promising candidate for subsequent fragment evolution, lead finding and optimization.
“This first phase of the integrated drug discovery collaboration with the ability to utilize structure-guided SAR, has progressed very rapidly, yielding significant results and information that will facilitate the eventual identification of innovative, therapeutically valuable lead candidates for our pipeline”, said Nick Renaldo, President at Revitocrine
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